Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1α under hypoxia …
M Ye, Z Fang, H Gu, R Song, J Ye, H Li, Z Wu… - Tumor …, 2017 - journals.sagepub.com
Hypoxia plays a critical role in the progression and metastasis of hepatocellular carcinoma
by activating the key transcription factor, hypoxia-inducible factor-1. This study aims to
identify the novel mechanisms underlying the dysregulation of hypoxia-inducible factor-1α in
hepatocellular carcinoma. We found that histone deacetylase 5, a highly expressed histone
deacetylase in hepatocellular carcinoma, strengthened the migration and invasion of
hepatocellular carcinoma cells under hypoxia but not normoxia condition. Furthermore …
by activating the key transcription factor, hypoxia-inducible factor-1. This study aims to
identify the novel mechanisms underlying the dysregulation of hypoxia-inducible factor-1α in
hepatocellular carcinoma. We found that histone deacetylase 5, a highly expressed histone
deacetylase in hepatocellular carcinoma, strengthened the migration and invasion of
hepatocellular carcinoma cells under hypoxia but not normoxia condition. Furthermore …
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